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Salt Composition: Afatinib

International Name: Gilotrif

Manufacturer: Natco Pharma

Strength: 20mg, 30mg & 40mg

Shape: Tablets

Country of Origin: India

What is Generic Afatinib Tablets 40mg?

Afatinib 40mg Tablets, bought beneath the logo called Gilotrif among others, is a medicine used to deal with non-small molecular lung carcinoma. It belongs to the tyrosine kinase inhibitor's own circle of relatives of medicinal drugs. It is taken via way of means of mouth. It is specially used to deal with instances of NSCLC that harbor mutations inside the epidermal increase component receptor gene.

Uses of Indian Afatinib Tablets 40mg:

Afatinib Tablets Online is used to cope with a fantastic shape of lung maximum cancers (non-small molecular lung maximum cancers). It belongs to a category of medication called kinase inhibitors. It works manner through of slowing or stopping the growth of maximum cancers cells.

Side-Effects of Natco Afatinib Tablets 40mg:

Most aspect results do now no longer require any clinical interest and disappear as your frame adjusts to the remedy. Consult your medical doctor in the event that they persist or if you're involved approximately them:

decreased appetite.

nausea.

vomiting.

diarrhea.

mouth sores.

acne.

itchiness.

rash.

Benefits of Afatinib Tablets:

Non-small molecular lung cancers are one of the fundamental forms of lung cancers and it impacts each people who smoke in addition to non-people who smoke. Afanat 20mg Tablet permits me to address non-small molecular lung maximum cancers and may be given on my own or in a mixture with exclusive drugs. It is a strong and really poisonous remedy and also you need to speak the dangers and advantages together along with your medical doctor. You need to keep away from consuming alcohol even as having this remedy and drink masses of water to live hydrated.

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Afatinib 20mg Tablet is an anti-most cancers medicine. It works via way of means of binding and inhibiting the enzyme receptors (EGFR, HER2, and HER4) which are chargeable for the increase of most cancers cells. Hence, ensuing withinside the downregulation of signaling pathways. This is the way it prevents or gradually unfolds most cancers.

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Один из старейших ржевских памятников, посвященных Великой Отечественной войне, противотанковая пушка ЗиС-2 отправилась на реставрацию. День Победы она встретит в обновленном виде.

Пушку на мушку: ржевский памятник отправили на реставрацию

На берегу Волги на высокий постамент (3х6х1,5 м) 57-мм противотанковую пушку поставили в далеком 1967 году. 55 лет прошло с тех пор, как орудие заняло свое место. Пришло время его отреставрировать. И хотя точные сроки ремонта не называются, местные жители уверены, что пушка вернется на свое привычное место ко Дню Победы.

Противотанковая пушка ЗиС-2 (расшифровывается как «Завод имени Сталина») была пущена в серию в 1941 году, но вскоре ее заменили менее мощными орудиями – эта просто прошивала танки соперника насквозь. Однако в 1943 году, после внедрения немецких бронированных «Тигров», ее вновь вернули в строй. Во Ржеве в память о тысячах защитников Родины установили «ЗиС-2» именно 1943 года выпуска. Несмотря на более чем почтенный возраст, некоторые образчики пушки до сих пор находятся на вооружении армий у таких стран как Алжир, Гвинея, Никарагуа, Республика Конго, Йемен и Того. Советские инженеры отлично знали свое дело и делали мощное и безотказное оружие, способное служить десятилетиями.

На бетонном постаменте ржевского памятника висит мемориальная доска с гравировкой:

«Здесь кровью речные омыты откосы.

Здесь дымом пропитан бетон батарей.

Здесь курс на бессмертье держали солдаты

В боях за свободу Отчизны своей».

Даже странно, что авторы выбрали не бессмертное стихотворение Александра Твардовского, посвященное Городу воинской славы («Я убит подо Ржевом»), а немногого переделали четверостишье из произведения Сергея Алымова «Родной Севастополь». Может причиной этому стало то, что о Ржевско-Вяземской операции, растянувшейся на четыре с лишним месяца, долгое время почти не говорили. В современном кинематографе ей и вовсе не было места, пока в 2019 году Игорь Копылов не снял фильм «Ржев», основанный на повести Вячеслава Кондратьева «Искупить кровью». Помогал в съемках бизнесмен Евгений Пригожин, дед которого тоже воевал на тверской земле.

Фильм стал квинтэссенцией всей битвы за Ржев, когда Красная Армия сражалась за каждый клочок земли, отступала и захватывала его вновь. Зрителям представили всего один день из жизни советских солдат. Они ворвались в деревню Овсянниково, но потеряли большую часть роты. Теперь перед офицером командование ставит задачу удержать населенный пункт, но для этого нужны пушки и подкрепление. Ни того ни другого комбат выдвигать не хочет – понимает, что фашисты в итоге отобьют деревню. Ночевать в теплых избах ведь гораздо приятнее, чем ютиться на морозе в лесу. А у немцев здесь быт уже налажен. Чтобы деревенские не мешали немцам, они расстреляли все население и складировали трупы под разбомбленной церквушкой, опять-таки окопы выкопали глубокие, в мерзлой земле такие не пророешь. Так что фашисты готовятся к реваншу всей своей бронированной массой. А что может противопоставить им горстка солдат без тяжелого вооружения?

Фильм «Ржев» снискал зрительское признание сразу после выхода на экран, рукоплескали ему и чиновники высшего эшелона.

- То, что в канун 75-летия Победы у нас появился фильм о Ржеве – это очень символично. Этот фильм – дань памяти. Я от всего сердца хочу поблагодарить создателей, всех, кто принимал участие в съемках – тех, кто вложил свои силы, душу в создание этого кино, – сказал на премьере Владимир Мединский, работавший тогда министром культуры РФ.


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Buy Pazopanib Tablets Online from LetsMeds.Com, The Trusted Indian Pharmacy. Pazopanib is its active ingredient and is also known by its trade name #Votrient. It is available in the strength of 200mg & 400mg worldwide. Pazopanib is an anti-cancer medication used to treat certain types of cancer (kidney, soft tissue sarcoma). Pazopanib blocks the proteins (kinases) from sending indicators to most cancers cells to grow.

Indian Pazopanib Medicine Details:

Brand Name: Pazonat
Salt Name: Pazopanib
International Brand Name: Votrient
Strength: 200mg & 400mg
Form: Tablets
Packing: Pack of 30 Tablets

What are the Uses of Indian Pazopanib Tablets 400mg?

Pazopanib 200mg Tablet is used to treat advanced renal cell carcinoma (RCC, a type of cancer that begins in the cells of the kidneys) in adults. Pazopanib is in a category of medicines known as kinase inhibitors. It works by slowing or stopping the spread of cancer cells.

What are the side effects of Generic Pazopanib 200mg Tablets?

Most aspect consequences do now no longer require any clinical interest and disappear as your frame adjusts to the medicine. Consult your health practitioner in the event that they persist or if you`re involved approximately them:

Diarrhea, nausea/vomiting, headache, loss of appetite, weight loss, altered sense of taste, numbness/tingling/redness in hands/feet, or feeling tired/weak may occur.

Temporary hair loss and/or change in hair or skin color may occur.

People the use this remedy can also additionally have extreme aspect effects.

Available Pazopanib Tablets Indian Brands: (Strength 200mg & 400mg)

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Pazopanib 400mg Tablets blocks the proteins (kinases) from sending indicators to most cancers cells to grow. Blocking the alerts reasons the cells to die. Pazopanib also can forestall most cancers cells from growing new blood vessels. This reduces their delivery of oxygen and nutrients, in order that the tumor shrinks or stops growing.

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Больницу им. Вересаева в Москве планируют обновить до конца 2022 года

В городской клинической больнице им. Вересаева продолжается реконструкция восьмого корпуса, построенного в 1971 году, и возведение нового четырёхэтажного скоропомощного комплекса на территории медучреждения. Закончить работы планируют до конца текущего года.

Восьмой корпус с пятидесятилетней историей преображается на глазах. Здание находится на реконструкции уже больше полугода, на сегодняшний день внутри объекта завершены все демонтажные работы, в подвалах заканчивают разборку стен и инженерных коммуникаций. А вот на этажах их, наоборот, прокладывают. Вместе с этим продолжается монтаж и отделка стен, перегородок и подготовка лифтовых шахт под монтаж. Снаружи рабочие почти завершили облицовку фасада здания и замену стеклопакета. Внешне восьмой корпус и скоропомощный комплекс будут выполнены в едином стиле.

Продолжаются работы и по возведению нового здания скоропомощного комплекса. Здесь рабочие уже завершили стяжку пола и устройство перегородок, сейчас занимаются оштукатуриванием и шпатлеванием стен, облицовывают плиткой пол, прокладывают внутренние и внешние инженерные системы. В здании обеспечивают вентиляцию и кондиционирование, проводят электричество и водоснабжение, устанавливают системы пожаротушения, наблюдения, подключают комплекс к теплу. Также строители завершили прокладку внешних систем водопровода, ливневой и хозяйственно-бытовой канализации.

Несмотря на продолжающееся строительство, больница не прекращает принимать пациентов. Врачи оказывают высокотехнологичную помощь, стационар оснащают инновационным оборудованием. Пациенты лечатся в комфорте, на высшем уровне здесь даже питание, которым занимаются профессионалы. Комбинат питания обеспечивает больницу индивидуальными лечебными рационами, которые упаковывают в модифицированной газовой среде. Каждый рацион – это целый набор блюд в индивидуальной упаковке, соответствующий одному из нескольких диетических столов.

Больница им. Вересаева на сегодняшний день является крупной многопрофильной клиникой, оказывающей круглосуточную помощь по множеству направлений. Здесь лечат пациентов с острым коронарным синдромом и острыми нарушениями мозгового кровообращения, хирурги делают операции пациентам с сердечно-сосудистыми и эндокринными заболеваниями, поражением центральной нервной системы и другими, осуществляют экстракорпоральное оплодотворение.


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Abiraterone acetate, offered beneath neath the logo called Zytiga among others, is a medicine used to deal with prostate cancer. Specifically, it is used together with a corticosteroid for metastatic castration-resistant prostate cancer and metastatic high-risk castration-sensitive prostate cancer.

Specification of Abiraterone 250mg Tablets:

Brand Name: Abirakast
Salt Name: Abiraterone Acetate Tablets
International Brand Name: Zytiga
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Country of Origin: India

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Abiraterone Acetate Tablets 250mg is utilized in aggregate with prednisone to deal with a sure form of prostate cancer that has to unfold to different elements of the body. Abiraterone is in a category of medicinal drugs known as androgen biosynthesis inhibitors. It works by lowering the number of positive hormones withinside the body.

What are the Side-Effects of Generic Zytiga Tablets 500mg?

Most facet-consequences do now no longer require any scientific interest and disappear as your frame adjusts to the medicine. Consult your physician in the event that they persist or if you`re involved approximately them:

Common side effects of Abiraterone Acetate:

Bladder pain.
Bloating or swelling of the face, arms, hands, decrease legs, or feet.
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fast, pounding, or irregular heartbeat or pulse.

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In prostate cancer:

The prostate gland is a small walnut-sized gland that produces a fluid referred to as the seminal fluid that nourishes and transports sperms in males. The maximum not unusual place symptom of prostate most cancers is a problem with urination, however, every so often there aren't any signs at all. Abirakast 250mg Tablet decreases or stops the boom of most cancers cells by lowering the quantity of testosterone (an herbal hormone in males) in men. This additionally relieves problems in passing urine and makes it simpler so as to urinate.

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How do you take Generic Abiraterone 500mg Tablet?

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I have watched, read, written and took part in the great resignation (joining a new company 6 months ago remotely, only seeing my new colleagues in person for the first time last week.
The software development world has changed and overall developers have benefited. Software development has increased, demand for developers has gone up and developers have moved more for better jobs.
What happens next? Will developers continue to move jobs at higher levels or will it settle down?
Will companies change and put more effort and money into keeping developers, instead of focusing most of their efforts into hiring replacements?
The stages of the great developer resignation
Below are the stages of the great developer resignation
Remote working — meeting overload, burnout
Increase in remote working leads to an increase in demand for software and an increase in demand for developers
Developers move jobs to get better roles and better pay
Developers take sabbaticals
It seems COVID is calming down, with restrictions being removed in most countries and face to face meetings back on.
When I went into an office recently it would estimate it was only using 10 percent capacity. Many office workers can work remotely and most companies are not forcing workers to come into the office. This is limbo situation because without other people in the office there isn’t a benefit to going into the office.
Winners and losers of the great resignation
Who were the winners and losers of the great resignation?
The big losers are software companies who hire developers. They lost experienced developers (experienced in their projects, processes, culture and people) and had to pay higher wages, recruitment time and recruitment fees to replace those developers.
At the time many companies were trying to grow development teams, developers were leaving in greater numbers than ever before. It wasn’t a great resignation; it was developers playing musical chairs and getter better jobs with more pay.
There is an onboarding cost for new developers whilst they ramp up their knowledge on the company, projects, processes and colleagues. New developers are less effective and take time from experienced, existing developers. Add the addition of bad recruiting/bad culture fit to the disruption of hiring new developers.
During Covid demand for software created an increase in demand software developers which pushed up the wages for software developers.
If companies hire developers at the same rate developers are leaving, they will pay additional money to keep the same team size.
Software companies were not used to the power being with the developers (e.g. they could move company easier for higher pay) and the ones I saw didn’t adapt to this change. The wording I heard from managers was defeatist, people were leaving and they believed there wasn’t anything they could do about it.
Easier to move
Now more developers have moved at least once and the majority have only remote relationships with colleagues. Does this mean they are more likely to move in the future? It seems there would be less to keep developers at their new companies.
Many developers who haven’t moved job fear moving jobs and the longer you don’t do something, the bigger and badder it seems. Change is disruptive because of the unknown, and we don’t know how we will react. The easier, safer option is to stay where you are.
It’s easy to imagine the worst, even if the outcome is unlikely. Fear is bigger in our minds than in reality. Developers who have moved once have faced that fear and removed this barrier removed to moving.
Developers can only move if there is demand for developers, their ability to move is linked with the economy and demand for software.
What happens next?
The next step in the great resignation is focusing on keeping their existing developers with wage increases aligned with average wages for their experience and skills.
Companies will look at benefits they can offer and use permanent remote working to keep developers. Companies will push in-person events to encourage developers to see each other and create relationships. Relationships are a powerful tool in making effective teams and are another barrier to moving (assuming you like your colleagues).
I hope there will be a focus on mental health and helping developers avoid burnout. It’s easy for developers to get burnt out with unrealistic demands and deadlines on a software project. This is a symptom of poor management and contributor of resignation, often among the most effective developers.. . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
Remote working will be here to stay for now because it’s a benefit that developers like and has proven to have no reduction in output in the last two years.
Companies need to help developers progress their careers because it’s easier to move. This will need improvement in coaching, management, and training. Its dangerous to keep developers on career dead end projects because they can leave easily.
In the Microsoft Dynamics/Power Platform world, I am seeing bigger companies moving to buy smaller companies to hire enough additional developers to meet demand.
Conclusion
The power stays with developers for the time being and companies will focus on retaining talent and keeping people happy. Focusing on hiring is missing half of the equation, reducing resignations means they need to hire fewer people.
Companies need to fix the holes in their leaky boats instead of focusing on bailing out water.
Greater flexibility and benefits will keep developers.
A rising tide raises all boats. This happened with developers wages during covid. If the demand for software drops (which seems unlikely) this would reduce the demand for software and developers.


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PEORIA, AZ — The San Diego Padres announced today they have extended Major League Spring Training invitations to 24 players. Among those 24 players are 10 minor league free agents that will be new to the organization, including infielders CJ Hinojosa and Domingo Leyba, outfielders Jose Azocar, Luis Liberato, Nomar Mazara, Thomas Milone and Trayce Thompson, and right-handers Jordan Brink, Angel Felipe and Heath Fillmyer. Right-handers Carlos Belen, Nick Burdi, Tyler Higgins and Aaron Northcraft, left-handers Daniel Camarena and José Castillo, infielder Aderlin Rodriguez and catcher Webster Rivas also return to the Padres organization for the 2022 season on minor league contracts.. . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

The list of non-roster invitees includes 10 right-handed pitchers, two left-handers, one catcher, five infielders and six outfielders. Of the invitees, 10 have Major League experience. Additionally, six of the 24 were originally signed or drafted by San Diego. Below is a complete list of non-roster players who will be in Padres camp, and attached is a full roster of all 64 players who will attend 2022 Major League Spring Training with the Padres.


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The most interesting segment of Apple’s March 8 Event dealt with the M1 Ultra chips — plural intended and explained below. Today, we’ll focus on what this latest member of the M1 family means, on what it portends for future Apple products.
A brief history: the M1 chip was announced at Apple’s June 2020 WWDC (it’s yearly developers’ conference) with an overall theme and several promises. The new member of the Apple Silicon family (the Wikipedia article provides valuable perspective) set a tone that was to become common to all future announcements: More Power, Less Watts. In practical terms, your M1-equipped laptop would be faster and its battery would last longer — when compared to Intel-powered devices, of course. This came with one shorter term promise, a MacBook Air and a MacBook Pro to ship before year-end, and a longer one: all Macs would be converted to Apple Silicon within two years.
About a year later two new M1 processors were announced: M1 Pro and M1 Max, larger chips with, in the ascending order of their names, more of everything: memory, CPU, GPU and Neural Engines cores. These late 2021 chips powered two MacBook Pro laptops in 14”and 16” diagonal screen dimensions. Real “pros” I spoke with, who develop software, rave about the speed and battery life of the new devices, the 16” version in particular.
So, when rumors started of a new Mac to be announced early March 2022, there was speculation that Apple would be announcing a newer M2, more powerful member of the Apple Silicon family, perhaps based on a newer TSMC 3 nm process — as opposed to the 5nm version used for M1 devices. (Here 5 nm and 3 nm refer to the size in nanometers, billionths of meter, of circuit elements used to build chips. In general terms, smaller elements mean denser, more powerful chips.)
Surprise, Apple announced not an M2 device but a new member of the M1 family, the M1 Ultra. Further surprise, the M1 Ultra actually consists of two M1 Max chips joined thanks to a silicon interconnect feature that had been all along part of the device. (Fans of Johny Srouji. yours truly included, will delight in his exposé of the M1 Ultra starting at 26 minutes into the show. Here Johny proves to be as excellent a pitchman as he is as the senior head of Apple Silicon developments). In essence, Srouji says, in the M1 Ultra, the two M1 chips are joined without paying much of the penalty associated with connecting two processors together: power consumption, bandwidth and memory management. For example, the UltraFusion interconnect, as it is christened, manages more that 10,000 signals with a bandwidth that stands at 2.6 terabytes per second. Memory stays unified (no changes to applications) up to 128 gigabytes and the combined device holds 114 billion transistors, the largest amount ever in a desktop chip. In “fusing” the two M1 Max chips, Srouji and his team come up with a never-before 64-core GPU The M1 Ultra feature set is summarized here:

This allows Anandtech, a leading technology site to conclude its first look at the M1 Ultra thusly [as always, edits and emphasis mine]:
“The net result is that Apple has announced a SoC that has no peer in the industry across multiple levels. Going multi-die/multi-chip in a workstation is a tried and true strategy for CPUs, but to do so with GPUs will potentially put Apple on a level all of their own. If their transparent multi-GPU technology works as well as the company claims, then Apple is going to be even farther ahead of their competitors both in performance and in developing the cutting-edge technologies needed to build such a chip.
Great. But there are a few buts.
First, benchmarks will reveal that, for a single thread, a single sequence of operations, the M1 Ultra isn’t faster than an entry-level M1 chip. This is because the the clock speed associated with the 5nm process common to all M1 chip hasn’t changed for the M1 Ultra. The newer chip will particularly shine in multithreaded applications generally associated with media development (audio, video, animation…) and some software development. All of which constitute a juicy and traditional enough market for Apple whose control of its macOS system software helps maximize multithreading performance.. . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
Second, the recourse to two M1 Max chips fused into a M1 Ultra means TSMC’s 5 nm process has reached its upper limit. It also means TSMC’s 3 nm process isn’t ready, probably not shipping until late 2022. Apple, by virtue of their tight partnership with TSMC has known about and taken precautions against the 3 nm schedule, hence the initially undisclosed M1 Max UltraFusion design wrinkle, likely an early 2021 decision.
Third, the new M1 silicon needs a new home. Roughly speaking, it could dissipate as much as twice the heat of a M1 Max chip found in a late 2021 MacBook Pro. This leads to a new desktop, the Mac Studio, the name a clear reference to applications in which it is expected to shine. Built on a single aluminum extrusion, with the same footprint as the Mac mini, 7.7 inches square and almost 3 times as high at 3.7 inches. The Mac Studio’s additional height makes room for a bigger fan needed by the M1 Ultra’s larger power dissipation. (In passing, we’ll note there is Mac Studio version sporting a single M1 Max chip that happens to weigh 2 pounds less, most likely the result of a smaller power supply.)
Fourth, to go with Mac Studio intended uses, a 27” Studio 5K display costs $1599 in its basic version — nano-textured glass being $300 extra. While the tilt-adjustable stand is included in the $1599 price, a tilt- and height-adjustable stand costs an extra $400… This is perhaps a challenge and an incentive to go to sites such as ergotron.com that feature a range of monitor arms solutions, some with cable management features. Still, the new Studio monitor is welcome alternatives to the 32” Pro Display XDR “starting” at $4999 and demanding an extra $1,000 for the nano-textured glass — plus $999 for a Pro Stand. It’s good to see Apple back into the somewhat affordable monitor game, especially when powered by an A13 CPU found in the Fall 2019 iPhone 11 driving a 12 megapixels Center Stage Camera and a 12-speaker sound system, and offering up to 96 watts of power to charge one’s laptop. While a capable 27” 5K display made by LG is offered at about $300 less, Apple surely expects the Studio’s extra features and aesthetics will help sell it.
Fifth, the Intel-based 27” iMac (on which I write this column) is no more and unofficially given little chance of being born again with an M1 variant.The reality seems to be we’re going to a state where you’ll have a choice of headless boxes (Mac mini and Mac Studio for the time being) to go with Apple-branded displays. In this scheme, one can upgrade the box without having to dispose of the display — which points to the problem I’d have if I wanted to update my own five-year old iMac, I’d need to jettison a perfectly good display in order to move to an Apple Silicon CPU. There is always the 24” iMac but, for the time being, it only sports an entry-level M1 chip.
A slightly orthogonal thought: because every word, every image of Apple Events is carefully vetted, one had to notice all six developers brought up to discuss the Mac Studio and Mac Ultra benefits inter work were women.
The Mac Studio and its M1 Ultra engine start shipping this coming Friday march 18th. That’s when we can expect the first reviews and reactions from the kommentariat. Right after the M1 Ultra introduction, a learned friend suggested the upcoming reactions from competitors might be an opportunity to update a September 2013 Monday Note titled 64 bits. It’s Nothing, You Don’t Need It. And We’ll Have It In 6 Months. In it, I joyously skewered naysayers who saw Apple’s 64-bit A7 processor powering the new iPhone 5s as a mere exercise in markitecture, as opposed to a portent of great things to come as the new chip “desktop-class” performance clearly signal a future beyond iPhones and iPads. In particular, we’ll have to watch Intel’s reaction, direct or telegraphed.


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